We be given to think of our bones as just scaffolding , withstand up our droopy material body and preclude it from flopping into a despicable , messy blob on the base . But our bones , and more specifically the cells that develop them , play a far more alive roleinour bodies than we generally believe .
In a novel subject , scientist have finally figured out more about how our osseous tissue affect how wemetabolize both lettuce and fat .
Our bones rely on hormones for many things , but most specifically for strength . When a teen ’s bones are grow , low estrogen or testosterone levels can run to their os becoming weaker . At the opposite end , when cleaning lady go through change of life , their production of estrogen drop-off and they become more prone to osteoporosis . But this communications go both path .
When research worker discovered the hormone osteocalcin , they found that the bone itself can affect other tissues . This hormone is think to play a part in the breakage down of scratch and fat by making it well-heeled to do so . “ One of osteocalcin ’s functions is to increase insulin product , which in turn reduces blood glucose levels,”explainsco - source Mathieu Ferron . “ It can also protect us from obesity by increase energy expenditure . ”
But while it was fuck that the cells that create osseous tissue , know as osteocytes , made a precursor to the hormone , it was still unknown how this was transformed into the run hormone when it was secreted from the pearl into the bloodstream . Now , in a work published inThe Journal of Clinical Investigation , researcher have identified an enzyme present in the os , call furin , which in effect snips off a part of the inactive harbinger to make it the dynamic hormone .
Intriguingly , the researchers also found that when they inactivate this enzyme , it reduced the appetite of computer mouse . But further investigation institute that it was not because osteocalcin was no longer being in good order produced , as the team went on to show that the hormone itself does not actually feign appetite .
“ Our issue propose the world of a new bone hormone that controls food intake,”saysFerron . “ In future workplace , we hope to determine whether furin interacts with another protein involved in appetite regulation . ”
